The protein encoded by this gene binds to the 'plus' endsof actin monomers and filaments to prevent monomer exchange. Theencoded calcium-regulated protein functions in both assembly anddisassembly of actin filaments. Defects in this gene are a cause offamilial amyloidosis Finnish type (FAF). Multiple transcriptvariants encoding several different isoforms have been found forthis gene.
Pathway
Amyloids; Apoptosis; Apoptotic cleavage of cellular proteins; Apoptotic execution phase; Caspase cascade in apoptosis; Caspase-mediated cleavage of cytoskeletal proteins; Coregulation of Androgen receptor activity; Disease;
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