Anti-CTGF monoclonal antibody, clone 669DU45.5.5

Antibody Isotype

IgG2b

Clone

669DU45.5.5

Species Reactivity

Human

Immunogen

Recombinant fragment (His-tag) corresponding to Human CTGF aa 166-193.Database link: P29279

Conjugate

Application Notes

IHC-P: 1/50; WB: 1/100 - 1/800.

Alternative Names

CTGF; connective tissue growth factor; CCN2; IGFBP8; IBP-8; IGFBP-8; CCN family member 2; IGF-binding protein 8; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8; NOV2; HCS24; MGC102839;

Entrez Gene ID

UniProt ID

Antigen Description

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Pathway

Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem;