Anti-CTGF monoclonal antibody (DMABT-H16164)

Mouse anti-Human CTGF monoclonal antibody for ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
3D22
Species Reactivity
Human
Immunogen
CTGF full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
CTGF; connective tissue growth factor; CCN2; IGFBP8; IBP-8; IGFBP-8
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CTGF (Connective Tissue Growth Factor) is a Protein Coding gene. Diseases associated with CTGF include systemic scleroderma and renal fibrosis. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include growth factor activity and integrin binding. An important paralog of this gene is NOV. The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
Antigen Description
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of cancers. 0The function about CTGF antigen include fibronectin binding; growth factor activity; heparin binding; insulin-like growth factor binding.
Pathway
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem.

Citations


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References


Chen, CY; Han, XY; et al. Serotonin drives the activation of pulmonary artery adventitial fibroblasts and TGF-beta 1/Smad3-mediated fibrotic responses through 5-HT2A receptors. MOLECULAR AND CELLULAR BIOCHEMISTRY 397:267-276(2014).
Wu, KJ; Huang, GF; et al. Cyclosporine A induces connective tissue growth factor expression in human gingival fibroblasts: Suppression by epigallocatechin-3-gallate. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 113:828-832(2014).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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