Anti-Ceruloplasmin monoclonal antibody, clone MAFB4020

Antibody Isotype

IgG2a

Clone

MAFB4020

Species Reactivity

Human

Immunogen

Purified mouse monoclonal antibody generated using E.coli expressed recombinant protein Ceruloplasmin as immunogen, corresponding to fragment(aa/933-1065) Ceruloplasmin.

Conjugate

Alternative Names

CP; ceruloplasmin (ferroxidase); ceruloplasmin; CP-2;

Entrez Gene ID

UniProt ID

Antigen Description

Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948. It is an enzyme synthesized in the liver containing 6 atoms of copper in its structure. Ceruloplasmin carries about 70% of the total copper in human plasma. Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) into Fe3+ (ferric iron), therefore assisting in its transport in the plasma in association with transferrin, which can only carry iron in the ferric state. The molecular weight of human ceruloplasmin is reported to be 151kDa.

Pathway

HIF-1-alpha transcription factor network, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Metal ion SLC transporters, organism-specific biosystem; Porphyrin and chlorophyll metabolism, organism-specific biosystem; Porphyrin and chlorophyll metabolism, conserved biosystem; SLC-mediated transmembrane transport, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem;