Ceruloplasmin Assay Kit

Sample

Serum, Plasma, Other biological fluids

Species Reactivity

Species-independent

Detection Method

Enzymes Assay

Intended Use

Detection and quantification of Ceruloplasmin (CP) activity in serum, plasma, and other biological fluids samples.

Contents of Kit

Storage

2 - 8°C

General Description

Ceruloplasmin is a copper containing protein found primarily in the blood. It carries approximately 70% of the total copper present in the blood. Ceruloplasmin exhibits a weak oxidase activity, which is a more accurate method of assessing ceruloplasmin in serum than immunodiffusion or other non-enzymatic assays. Normal Ceruloplasmin levels are generally 1-4 μM (15-60 mg/dl), equivalent to approximately 50-150 mU/mL. Elevated amounts of serum ceruloplasmin are found in pregnancy, cancer, rheumatoid arthritis and in several mental conditions such as Alzheimer's, schizophrenia and OCD. Abnormally low amounts are found in Wilson's and Menkes' Diseases and in several other rare conditions. The assay is initiated with the enzymatic catalysis of the PPD by CP. The enzyme catalyzed reaction products can be measured at a colorimetric readout at 540 nm.