Anti-Ceruloplasmin monoclonal antibody, clone 4C12

Antibody Isotype

IgG1

Clone

4C12

Species Reactivity

Human

Immunogen

Protein purified from Human plasma

Conjugate

Alternative Names

CP; ceruloplasmin (ferroxidase); ceruloplasmin; CP-2;

Entrez Gene ID

UniProt ID

Antigen Description

Ceruloplasmin, 132kDa, is a serum ferroxidase that contains greater than 95% of the copper found in plasma. This protein is a member of the multicopper oxidase family an evolutionarily conserved group of proteins that utilize copper to couple substrate oxidation with the four-electron reduction of oxygen to water. Despite the need for copper in ceruloplasmin function, this protein plays no essential role in the transport or metabolism of this metal. Serum ceruloplasmin level is reduced in Wilson"s disease, malnutrition nephrotic syndrome and increased in pregnancy, oestrogen containing contraceptives, acute infection, some types of chronic liver disease, malignancy, rheumatoid arthritis.

Pathway

HIF-1-alpha transcription factor network, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Metal ion SLC transporters, organism-specific biosystem; Porphyrin and chlorophyll metabolism, organism-specific biosystem; Porphyrin and chlorophyll metabolism, conserved biosystem; SLC-mediated transmembrane transport, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem;