Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Pathway
APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of mitotic proteins; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins; Cell Cycle; Cell Cycle Checkpoints; Cell Cycle, Mitotic; Cell cycle
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