This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Pathway
APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of mitotic proteins; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins; Cell Cycle; Cell Cycle Checkpoints; Cell cycle; HTLV-I infection; Inactivation of APC/C via direct inhibition of the APC/C complex
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