General Notes
This product (Catalog No. DPABH-28572) is a rabbit-derived polyclonal antibody raised against human BMI1, targeting the amino acid region 152–289 of the protein. This antibody exhibits cross-reactivity with Human BMI1 from mouse and rat. It has been affinity purified by Protein A. BMI1 (Bmi1 proto-oncogene, polycomb ring finger 1) is a gene that encodes a core component of the Polycomb repressive complex 1 (PRC1), a multiprotein assembly crucial for chromatin remodeling and transcriptional repression through histone ubiquitination. This protein plays an essential role in regulating gene expression by maintaining repressive chromatin states, particularly at key developmental loci such as Hox genes, thereby influencing cell fate decisions during embryogenesis. BMI1 is indispensable for the self-renewal and maintenance of various stem cell populations, including hematopoietic, neural, and mammary stem cells, by preventing premature senescence and promoting proliferation. Dysregulation of BMI1, often through overexpression, transforms it into an oncogene implicated in multiple human cancers, where it drives tumorigenesis by inhibiting tumor suppressors like p16^INK4a and p19^ARF.
DPABH-28572 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-28572 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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