This product was produced with the following immunogens:Synthetic peptide corresponding to Mouse Bmi1 aa 150-250 conjugated to Keyhole Limpet Haemocyanin (KLH).Database link: P25916Synthetic peptide corresponding to Mouse Bmi1 aa 100-200 conjugated to Key
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/100.
Target
Alternative Names
BMI1; Bmi1 polycomb ring finger oncogene; polycomb complex protein BMI-1; polycomb group ring finger 4; B lymphoma Mo-MLV insertion region 1; polycomb group RING finger protein 4; Bmi-1; Pcgf4; AW546694;
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Pathway
Senescence and Autophagy, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;
Citations
Publication ()
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COA
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