Anti-BMI1 monoclonal antibody, clone FQS4856(3) Knockout Validated

Antibody Isotype

IgG

Clone

FQS4856(3)

Species Reactivity

Rat; Human

Immunogen

A synthetic peptide, corresponding to residues in Human Bmi1 (UniProt P35226).

Conjugate

Application Notes

WB: 1/10000 - 1/50000; IHC-P: 1/100 - 1/250; ICC/IF: 1/100 - 1/250;

Alternative Names

BMI1; BMI1 polycomb ring finger oncogene; B lymphoma Mo MLV insertion region 1 homolog (mouse) , PCGF4, polycomb group ring finger 4; polycomb complex protein BMI-1; RNF51; flvi-2/bmi-1; ring finger protein 51; polycomb group protein Bmi1; polycomb group

Entrez Gene ID

UniProt ID

Antigen Description

Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Pathway

Senescence and Autophagy, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem; Validated targets of C-MYC transcriptional activation, organism-specific biosystem;