Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Pathway
Cellular Senescence; Cellular responses to stress; MicroRNAs in cancer; Oxidative Stress Induced Senescence; Senescence and Autophagy; Transcriptional misregulation in cancer; Validated targets of C-MYC transcriptional activation
Citations
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