Magic™ Anti-BAD (Phospho S118) polyclonal antibody

Four typical cases of storm tide inundation at one of the typical storm surge prone areas in China and worldwide, i.e. Southeast China coast, are presented to demostrate the impact of climate change. It is relied on the statistical trend analysis of tropical cyclone intensification (TCI) and sea level rise (SLR) considering temporally non-stationary and spatially non-uniform effects, numerical analysis taking into account the tide-surge-wave coupling effect and GIS-based analysis for inundation evaluation. The results show that the high sea surface elevation tends to occur in the bays and around the estuaries. The maximal sea surface elevations of the worst situation at present without considering TCI and SLR (i.e. scenario S2) are 6.06 m, 5.82 m and 5.67 m around Aojiang, Feiyunjiang and Oujiang river estuaries, respectively. Whereas, the maximal sea surface elevations for the three estuaries would increase to 7.02 m, 6.67 m and 6.44 m, respectively, when the non-stationary extreme wind speed of 100-year recurrence period and SLR equivalent to the situation of 2100s (i.e. scenario S4) are taking into account. The potential inundation area of scenario S4 would expand by 108% to about 798 km(2) compared with scenario S2. In addition, the remotely sensed maps and inundation durations of the hardest hit regions are provided, which will aid the prevention and mitigation of storm tide inundation hazard and future coastal management there. Graphic abstract

Background: Clinical characteristics and prognosis among combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (cHCC-CC) with HCC and intrahepatic cholangiocarcinoma (ICC) were inconsistent in previous studies. The aim of this study was to compare postoperative prognosis among cHCC-CC, HCC and ICC, and investigated the prognostic risk factor of cHCC-CC after surgical resection. Methods: A total of 1041 eligible patients with pathological diagnosis of cHCC-CC (n=135), HCC (n=698) and ICC (n=208) were enrolled in this study. Univariate and multivariate Cox analysis were applied for assessing important risk factors. cHCC-CC were further 1:1 matched with HCC and ICC on important clinical risk factors. Survival curves of matched and unmatched cohorts were depicted by Kaplan-Meier method with log-rank test. Results: Patients with cHCC-CC had similar rate of sex, age and cirrhosis with HCC (p<0.05) and comparable incidence of hepatitis B or C with ICC (1)=0.197). Patients of cHCC-CC had intermediate prognosis between HCC and ICC, with median overall survival (OS) time of cHCC-CC, HCC and ICC of 20.5 months, 35.7 months and 11.6 months (p<0.001). In matched cohorts, the OS of cHCC-CC were worse than HCC (p<0.001) but comparable with ICC (1)=0.06), while the disease-free survival (DFS) of cHCC-CC was worse than HCC but better than ICC (p<0.05). And lymph node infiltration and postoperative transarterial chemoembolization (TACE) were independent risk factors of cHCC-CC associated with prognosis. Conclusion: The long term survival of cHCC-CC was worse than HCC but comparable with ICC when matched on albumin level, tumor size, lymph node infiltration, tumor stage and margin. Presence of lymph node infiltration and no postoperative TACE were associated with poor prognosis of cHCC-CC.