BAD blocking peptide (DAG-P0004)

Synthetic BAD blocking peptide for BL Datasheet

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Specificity
Expressed in a wide variety of tissues.
Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Belongs to the Bcl-2 family.
Cellular Localization
Mitochondrion outer membrane. Cytoplasm. Upon phosphorylation, locates to the cytoplasm.
Alternative Names
Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Format
Liquid
Buffer
PBS with 100ug BSA 0.1% sodium azide
Storage
Store at +4°C. PBS with 100ug BSA 0.1% sodium azide
UniProt ID
Antigen Description
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
Function
cysteine-type endopeptidase activator activity involved in apoptotic process; lipid binding; phospholipid binding; protein binding; protein heterodimerization activity; protein kinase B binding; protein kinase binding; protein phosphatase 2B binding;
Synonyms
BAD; BCL2-associated agonist of cell death; BBC2; BCL2L8; bcl2 antagonist of cell death; bcl2-L-8; BCL2-binding protein; bcl-2-like protein 8; BCL2-binding component 6; bcl-2-binding component 6; BCL-X/BCL-2 binding protein; BCL2-antagonist of cell death protein; bcl-XL/Bcl-2-associated death promoter;

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