BAD blocking peptide

Name: BAD blocking peptide
SKU: CDBP5152
Rating: 5 (1 reviews)

Synthetic BAD blocking peptide for IB

COA

SDS

Datasheet

Summary

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Concentration

200 μg/mL

Preservative

None

Storage

-20°C

Entrez Gene ID

572

Antigen Description

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]

Function

cysteine-type endopeptidase activator activity involved in apoptotic process; lipid binding; phospholipid binding; protein binding; protein heterodimerization activity; protein kinase B binding; protein kinase binding; protein phosphatase 2B binding

Synonyms

BAD; BCL2-associated agonist of cell death; BBC2; BCL2L8; bcl2-associated agonist of cell death; bcl2-L-8; BCL2-binding protein; bcl-2-like protein 8; BCL2-binding component 6; bcl-2-binding component 6; BCL-X/BCL-2 binding protein; bcl2 antagonist of cell death; BCL2-antagonist of cell death protein; bcl-XL/Bcl-2-associated death promoter

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

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References

Six months as a cutoff time point to define early recurrence after liver resection of hepatocellular carcinoma based on post-recurrence survival

UPDATES IN SURGERY

Authors: Liu, Yueh-Wei; Yong, Chee-Chien; Lin, Chih-Che; Wang, Chih-Chi; Chen, Chao-Long; Cheng, Yu-Fan; Wang, Jing-Houng; Yen, Yi-Hao

Abstract

To determine the optimal cutoff time point of early versus late recurrence relative to post-recurrence survival (PRS) among patients who underwent liver resection (LR) for hepatocellular carcinoma (HCC) in a high-volume liver surgery center in East Asia. This was a retrospective study. Patients who underwent LR for HCC between 2011 and 2018 at Kaohsiung Chang Gung Memorial Hospital were enrolled. The optimal cutoff time point to differentiate early versus late recurrence was evaluated relative to PRS. Among 826 patients, 282 (34.1%) of the patients experienced recurrence, with a median time to recurrence of 12.2 months. 6 months was defined as the optimal cutoff time point based on sensitivity analyses relative to PRS. Ninety (31.9%) of the patients developed early recurrence within 6 months, and 192 patients (68.1%) developed late recurrence beyond 6 months. Early recurrence was associated with worse PRS (median PRS, 13.2 versus 48.9 months, p < 0.001), as well as overall survival (OS) (median OS, 16.2 versus 65.4 months, p < 0.001), than late recurrence. Six months was identified as the cutoff time point to differentiate early versus late recurrence among patients undergoing LR for HCC.

Simple and local independent set approximation

THEORETICAL COMPUTER SCIENCE

Authors: Boppana, Ravi B.; Halldorsson, Magnus M.; Rawitz, Dror

Abstract

We study the worst-case behavior of Turan-like bounds for unweighted and weighted independent sets in bounded-degree graphs. In particular, we revisit a randomized approach of Boppana that forms a simple 1-round distributed algorithm, as well as a streaming algorithm and a preemptive online algorithm. We show that it gives a tight (Delta + 1)/2-approximation in unweighted graphs of maximum degree Delta, which is best possible for 1-round distributed algorithms. For weighted graphs, it gives only a (Delta + 1)-approximation, but a simple modification results in an asymptotic expected 0.529(Delta + 1)-approximation. (C) 2020 Elsevier B.V. All rights reserved.