Anti-ATG3 monoclonal antibody, clone FQS5912

Antibody Isotype

IgG

Clone

FQS5912

Species Reactivity

Mouse; Rat; Human

Immunogen

A synthetic peptide corresponding to residues near the N-terminus in Human Apg3

Conjugate

Application Notes

WB: 1/10000 - 1/50000; IHC-P: 1/100 - 1/250; ICC: 1/100 - 1/250; IF: 1/100;

Alternative Names

ATG3; ATG3 autophagy related 3 homolog (S. cerevisiae); APG3 autophagy 3 like (S. cerevisiae) , APG3L; ubiquitin-like-conjugating enzyme ATG3; DKFZp564M1178; FLJ22125; MGC15201; PC3 96; hApg3; 2610016C12Rik; autophagy-related protein 3; APG3; APG3L; PC3-9

Entrez Gene ID

UniProt ID

Antigen Description

E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.

Pathway

Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem; Senescence and Autophagy, organism-specific biosystem;