Specifications
Immunogen
Synthetic peptide, corresponding to residues near the N-terminus in Human Apg3 (UniProt: Q9NT62).
Applications
Application Notes
ICC/IF: 1/100.
Target
Alternative Names
ATG3; ATG3 autophagy related 3 homolog (S. cerevisiae); APG3 autophagy 3 like (S. cerevisiae) , APG3L; ubiquitin-like-conjugating enzyme ATG3; DKFZp564M1178; FLJ22125; MGC15201; PC3 96; hApg3; 2610016C12Rik; autophagy-related protein 3; APG3; APG3L; PC3-9
Product Background
Antigen Description
E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.
Pathway
Regulation of autophagy, organism-specific biosystem; Regulation of autophagy, conserved biosystem; Senescence and Autophagy, organism-specific biosystem;
Citations
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Sakoh-Nakatogawa, M; Matoba, K; et al. Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site. NATURE STRUCTURAL & MOLECULAR BIOLOGY 20:433-+(2013).
Choy, A; Dancourt, J; et al. The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation. SCIENCE 338:1072-1076(2012).
COA
Certificate of Analysis
