This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Function
Atg12 ligase activity; Atg8 ligase activity; Atg8 ligase activity; enzyme binding; protein binding; small conjugating protein ligase activity
Synonyms
ATG3; autophagy related 3; APG3; APG3L; PC3-96; APG3-LIKE; ubiquitin-like-conjugating enzyme ATG3; hApg3; 2610016C12Rik; autophagy-related protein 3; ATG3 autophagy related 3 homolog
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