General Notes
This product (Catalog No. DPABH-16663) is a rabbit-derived polyclonal antibody raised against human ARAF, targeting the amino acid region 349–606 of the protein. This antibody exhibits cross-reactivity with Human ARAF from mouse and rat. It has been affinity purified by Protein A. Proto-oncogene A-Raf is a member of the RAF family of serine/threonine kinases and is encoded by the ARAF gene. A-Raf participates in the RAS–RAF–MEK–ERK signaling cascade, a major pathway regulating cell proliferation, differentiation, and survival. Compared with other RAF family members such as B-Raf and C-Raf, A-Raf generally exhibits lower intrinsic kinase activity but can modulate signaling output through protein–protein interactions and regulatory phosphorylation events. ARAF is expressed in various tissues, including urogenital and neural tissues, and has been implicated in developmental processes and oncogenic signaling when aberrantly activated. Although mutations in ARAF are less common than in other RAF genes, dysregulation of A-Raf signaling may contribute to tumorigenesis and abnormal cell growth.
DPABH-16663 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-16663 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
COA
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