Anti-ABCG2 (aa 1-110) polyclonal antibody

Species Reactivity

Human; Mouse

Immunogen

ABCG2 (NP_004818, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. The sequence is MSSSNVEVFIPVSQGNTNGFPATVSNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLING

Conjugate

Alternative Names

ABCG2; ATP-binding cassette, sub-family G (WHITE), member 2; MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; CDw338; UAQTL1; EST157481; ATP-binding cassette sub-family G member 2; urate exporter; ABC transporter; placenta specific MDR protei

Entrez Gene ID

UniProt ID

Antigen Description

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.

Pathway

ABC transporters; Abacavir transport and metabolism; Fluoropyrimidine Activity; HIF-2-alpha transcription factor network