Specifications
Immunogen
3T3 cells expressing human ABCG2
Applications
Application Notes
Flow Cyt: Use 10 μL per 106 cells in 100 μL volume Optimal working dilutions must be determined by end user.
Target
Alternative Names
ABCG2; ATP-binding cassette, sub-family G (WHITE), member 2; ATP-binding cassette sub-family G member 2; ABCP; BCRP; CD338; EST157481; MXR; ABC transporter; placenta specific MDR protein; breast cancer resistance protein; ATP-binding cassette transporter
Product Background
Antigen Description
Breast cancer resistance protein (BCRP1), also known as placenta-specific ATP-binding cassette (ABC) protein (ABCP) or ABC G-subfamily member 2 (ABCG2), or mitoxantrone resistance protein (MXR), is a member of the ATP-binding cassette superfamily of drug
Pathway
ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Fluoropyrimidine Activity, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem;
Citations
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Studzian, M; Bartosz, G; et al. Antibody opsonization-dependent internalization and trafficking of ABCG2 in cancer cell lines. FEBS JOURNAL 280:163-163(2013).
Shen, H; Lee, FY; et al. Ixabepilone, a Novel Microtubule-Targeting Agent for Breast Cancer, Is a Substrate for P-Glycoprotein (P-gp/MDR1/ABCB1) but not Breast Cancer Resistance Protein (BCRP/ABCG2). JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 337:423-432(2011).