Anti-ABCG2 monoclonal antibody, clone 2I3

Antibody Isotype

IgG1

Clone

2I3

Species Reactivity

Mouse; Human; Monkey

Immunogen

Purified recombinant fragment of Human BCRP/ABCG2 expressed in E. coli.

Conjugate

Application Notes

WB: 1/500 - 1/2000; ELISA: 1/10000; ICC/IF: 1/200 - 1/1000;

Alternative Names

ABCG2; ATP-binding cassette, sub-family G (WHITE), member 2; ATP-binding cassette sub-family G member 2; ABCP; BCRP; CD338; EST157481; MXR; ABC transporter; placenta specific MDR protein; breast cancer resistance protein; ATP-binding cassette transporter

Entrez Gene ID

UniProt ID

Antigen Description

Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

Pathway

ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Fluoropyrimidine Activity, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem;