Magic™ Anti-AATF (Phospho S477) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to Human AATF (phospho S477). Surrounding Serine 477.Database link: Q9NY61

Conjugate

Application Notes

WB: 1/1000

Alternative Names

AATF; apoptosis antagonizing transcription factor; DED; BFR2; CHE1; CHE-1; protein AATF; rb-binding protein Che-1; apoptosis-antagonizing transcription factor;

Entrez Gene ID

UniProt ID

Antigen Description

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Pathway

Cell death signalling via NRAGE, NRIF and NADE; Regulation of retinoblastoma protein; Signalling by NGF;