Product Overview
Blocking peptide for anti-AATF antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.
Buffer
PBS containing 0.02% sodium azide
Preservative
0.02% Sodium Azide
Storage
Store at -20℃, stable for one year.
Antigen Description
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.
Function
leucine zipper domain binding; protein binding; protein domain specific binding; sequence-specific DNA binding transcription factor activity; tau protein binding;
Synonyms
AATF; apoptosis antagonizing transcription factor; protein AATF; CHE 1; CHE1; DED; rb-binding protein Che-1; apoptosis-antagonizing transcription factor; CHE-1;
Citations
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Bellido, T; O'Brien, CA; et al. Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines - A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells. JOURNAL OF BIOLOGICAL CHEMISTRY 273:21137-21144(1998).
Biswas, RS; Cha, HJ; et al. Inhibition of drug-induced Fas ligand transcription and apoptosis by Bcl-X-L. MOLECULAR AND CELLULAR BIOCHEMISTRY 225:7-20(2001).