The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
Function
leucine zipper domain binding; poly(A) RNA binding; protein binding; sequence-specific DNA binding transcription factor activity; tau protein binding
Synonyms
AATF; apoptosis antagonizing transcription factor; DED; BFR2; CHE1; CHE-1; protein AATF; rb-binding protein Che-1; apoptosis-antagonizing transcription factor
Citations
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