The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
Pathway
Cell death signalling via NRAGE; NRAGE signals death through JNK; Regulation of retinoblastoma protein; Signal Transduction; Signalling by NGF; p75 NTR receptor-mediated signalling
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