ALB blocking peptide

Background: Serum albumin levels (ALB) and albumin-globulin ratio (AGR) are reliable and convenient markers of the nutritional status and inflammation of human body, and ALB has been identified as a prognostic factor in the patients of glioblastoma (GBM). However, no literature has reported the prediction value of AGR for GBM. Methods: In this study we evaluate the serum ALB and AGR levels for GBM. A total of 126 patients with GBM who underwent surgical resection in our institution between 2013 and 2017 were analyzed retrospectively. Clinical information was obtained from electronic medical records. Multiple logistic regression and Cox proportional hazards models were used to assess the prediction value of preoperative ALB and AGR for GBM. Results: Preoperative ALB (HR 0.342, 95% CI, 0.123-0.954, P=0.040) and postoperative adjuvant therapy (HR 0.042, 95% CI, 0.005-0.330, P=0.003) were significantly related to progression-free survival (PFS). Cox regression analysis showed the significance of adjuvant therapy (HR 3.579, 95% CI, 2.236-5.729, P<0.001). Preoperative AGR (HR 0.280, 95% CI, 0.103-0.763, P=0.013) and adjuvant therapy (HR 0.156, 95% CI, 0.047-0.513, P=0.002) were showed significance, and Cox regression analysis showed preoperative AGR (HR 1.810, 95% CI, 1.095-2.992, P=0.021) and adjuvant therapy (HR 4.702, 95% CI, 2.841-7.782, P<0.001) were independent predictors of overall survival (OS). Conclusions: The ALB and AGR had significant predictive values for the prognosis of GBM; postoperative adjuvant treatment is also an independent predictor for the prognosis of GBM patients.

Background: It has been recently reported that albumin (ALB) and red cell distribution width (RDW) are correlated with the prognosis of community-acquired pneumonia, while their role in severe community-acquired pneumonia (sCAP) is unknown. This study aimed to investigate the correlation between the ALB-RDW score and 90-day mortality of sCAP patients. Methods: A total of 179 sCAP patients admitted to our hospital between January 1, 2014 and June 30, 2019 were enrolled in this study. Data of patient characteristics and laboratory data were obtained and CURB-65 was calculated. The ALB-RDW score was calculated based on serum ALB and RDW. Receiver operating characteristic (ROC) curve and the value of area under the curve (AUC) were used to evaluate the association between ALB-RDW score and 90-day mortality of sCAP patients. Results: Compared with survivors, age, white blood cell counts, neutrophil counts, RDW, D-dimer, serum creatinine, lactic dehydrogenase, CURB-65 score, ALB-RDW high score ratio, invasive ventilation and septic shock were higher in non-survivors, while ALB and hemoglobin (HB) were lower. Multivariate logistic regression analysis identified that high age, serum creatinine, ALB-RDW score and invasive ventilation were the independent risk factors of 90-day mortality (P<0.05). Moreover, the AUC of ALB-RDW score was 0.742 [95% confidence interval (CI): 0.667-0.817], which was superior to CURB-65 score 0.725 (95% CI: 0.651-0.798). The AUC increased to 0.798 (95% CI: 0.733-0.862) when combined with CURB-65 score. Conclusions: High age, serum creatinine, ALB-RDW score and invasive ventilation were the independent risk factors of 90-day mortality of sCAP patients. In addition, the correlation between ALB-RDW and 90-day mortality was even stronger when combined with CURB-65 score.