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    3. Hi-Puri™ Anti-Human DR5 monoclonal antibody

    Hi-Puri™ Anti-Human DR5 monoclonal antibody

    Mouse Anti-Human DR5 monoclonal antibody for ELISA, FuncS

    Bring this labeled antibody directly to your bench!

    pdf COA pdf SDS pdf Datasheet
    Key features and details
    • DR5-01 and DR5-05 can recognize two distinct epitopes on DR5
    • Suitable for ELISA, FuncS
    • Isotype: IgG
    • Clonality: Monoclonal
    • Various conjugated forms available upon request.
    Specifications
    Antibody Isotype
    IgG
    Clone
    DR5-05
    Species Reactivity
    Human
    Immunogen
    The original antibody was obtained by immunizing mice with soluble recombinant human DR5 protein
    Conjugate
    Unconjugated
    Applications
    Application Notes
    ELISA, FuncS
    Each laboratory should determine an optimum working titer for use in its particular application.
    Other applications have not been tested but use in such assays should not necessarily be excluded.
    General Notes
    DR5-01 and DR5-05 are designed to induce apoptosis in cancer cells by targeting DR5, with potential applications in cancer therapy, particularly in tumor types with high DR5 expression levels. DR5-01 and DR5-05 have been reported that can bind to two distinct epitopes on DR5, enhancing their affinity and specificity to effectively induce apoptosis.
    Images
    Binding characteristics of DR5-01 and DR5-05.
    Binding of DR5-01 and DR5-05 to HCT 116 colorectal cancer (CRC) cells was measured by FC.
    *DR5-01 and DR5-05 were modified by adding an E430G hexamerization-enhancing mutation in the Fc domain to create Hx-DR5-01 and Hx-DR5-05.
    Crossblock binding ELISA with immobilized Hx-DR5-01 (left graph) and immobilized Hx-DR5-05 (right graph) in the presence of ECD of DR5 and the indicated competing antibodies. Data show percentage inhibition of binding to DR5 and is the mean of triplicate samples.
    *DR5-01 and DR5-05 were modified by adding an E430G hexamerization-enhancing mutation in the Fc domain to create Hx-DR5-01 and Hx-DR5-05.
    Target
    Alternative Names
    TNFRSF10B; TRAILR2; TRAIL-R2; CD262; DR5; KILLER; TRICK2; ZTNFR9; TRICKB
    Custom Antibody Labeling
    We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
    Citations
    Have you cited DMABB-JXR109 in a publication? Let us know and earn a reward for your research.
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