Anti-TNFRSF10B monoclonal antibody, clone FQS2760(3)

Name: Anti-TNFRSF10B monoclonal antibody, clone FQS2760(3)
SKU: DCABH-7355

Rabbit anti-Human TNFRSF10B monoclonal antibody for WB, FC, IP

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Clone

FQS2760(3)

Species Reactivity

Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human DR5 aa 400 to the C-terminus. The exact sequence is proprietary.Database link: O14763

Conjugate

Unconjugated

Applications

Application Notes

WB: 1/10000 - 1/50000; Flow Cyt: 1/400; IP: 1/30;

Target

Alternative Names

TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; apoptosis inducing rec

Entrez Gene ID

8795

UniProt ID

O14763

Product Background

Antigen Description

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Pathway

Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Caspase-8 is formed from procaspase-8, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;

Citations