Anti-TNFRSF10B monoclonal antibody, clone 8G5-G9-H22

Name: Anti-TNFRSF10B monoclonal antibody, clone 8G5-G9-H22
SKU: DCABH-6277
Rating: 5 (1 reviews)

Mouse anti-Human TNFRSF10B monoclonal antibody for WB, ICC/IF

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COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG1

Clone

8G5-G9-H22

Species Reactivity

Mouse; Human

Immunogen

Recombinant fragment within Human sTRAIL Receptor 2. The exact sequence is proprietary. Expressed in E.coli. NM_003842.Database link: O14763

Conjugate

Unconjugated

Applications

Application Notes

WB: 1/500 - 1/2000; ICC/IF: 1/100;

Target

Alternative Names

TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; apoptosis inducing rec

Entrez Gene ID

8795

UniProt ID

O14763

Product Background

Antigen Description

TRAIL Receptor 2 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Pathway

Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Caspase-8 is formed from procaspase-8, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem;

Citations