Anti-TNFRSF10B monoclonal antibody, clone NE6-2 Functional Grade

Name: Anti-TNFRSF10B monoclonal antibody, clone NE6-2
SKU: DCABH-5633
Rating: 5 (1 reviews)

Armenian Hamster anti-Mouse TNFRSF10B monoclonal antibody for FuncS, FC

Write a review

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Clone

NE6-2

Species Reactivity

Mouse

Immunogen

The details of the immunogen for this antibody are not available. corresponding to Mouse DR5.

Conjugate

Functional Grade

Applications

Application Notes

Flow Cyt: 0.25μg/10⁶ cells.

Target

Alternative Names

TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; death receptor 5; KILLER/DR5 TRAIL death-inducing receptor; MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B;

Entrez Gene ID

21933

UniProt ID

Q9QZM4

Product Background

Antigen Description

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.

Pathway

Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis signaling pathway, organism-specific biosystem; Caspase-8 is formed from procaspase-8, organism-specific biosystem;

Citations