Suitable for use to measure free Rituximab in patient samples.
Recommended antibody pair for pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB245 - CABT-ZB246; CABT-ZB245 - CABT-ZB247
Recommended Working Concentration: 0.01-0.1 μg/ml
Summary
Specifications
Antibody Isotype
IgG
Clone
248D7
Immunogen
Rituximab
Conjugate
Unconjugated
Applications
Application Notes
Suitable for use in PK bridging ELISA. We recommend the following for sandwich ELISA (Capture - Detection): CABT-ZB245 - CABT-ZB246; CABT-ZB245 - CABT-ZB247 Recommended Working Concentration: 0.01-0.1 μg/ml
General Notes
We recommend the following antibody pair to develop a pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB245 - CABT-ZB246; CABT-ZB245 - CABT-ZB247 CABT-ZB245 is recommended for use as a capture antibody when paired with CABT-ZB246 or CABT-ZB247 as a detection antibody. Rituximab (Rituxan) is a humanized monoclonal antibody that is approved by the U.S. Food and Drug Administration for the treatment of hematological cancers and autoimmune diseases. When Rituximab binds to CD20 on the surface of normal and malignant B cells, natural killer (NK) cells is activated to destroy these B cells. It is therefore used to treat diseases with too many B cells, overactive B cells, or dysfunctional B cells.
Target
Alternative Names
Rabbit monoclonal antibody to Rituxan; RITUXIMAB; Anti-CD20 antibody; MabThera
Citations
Publication ()
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