Product Overview
A DNA sequence encoding the SARS-CoV-2 papain-like protease (YP_009725299.1) (Glu1564-Val1880) was expressed with a polyhistidine tag at the N-terminus.
Molecular Weight
36.79 kDa
Alternative Names
SARS-CoV-2; coronavirus; SARS-CoV-2 Plpro; SARS-CoV-2 papain-like protease
Purity
> 90 % as determined by SDS-PAGE.
Buffer
Lyophilized from sterile 20mM Tris 500mM NaCl, pH 7.4.
Storage
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Introduction
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
Keywords
SARS-CoV-2; coronavirus; SARS-CoV-2 Plpro; SARS-CoV-2 papain-like protease
Citations
Publication ()
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