Product Overview
Recombinant SARS-CoV-2 NSP10 is produced by our E.coli expression system and the target gene encoding Ala1-Gln139 is expressed with a 6His tag at the N-terminus.
Alternative Names
SARS-CoV-2 NSP10; SARS-CoV-2
Purity
Greater than 80% as determined by reducing SDS-PAGE.
Buffer
Supplied as a 0.2 um filtered solution of PBS, 10% Glycerol, pH 7.4.
Storage
Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Introduction
Nsp10 have shown that it is a 15-kDa protein of unknown function that has been shown to interact with itself, nsp1, and nsp7. It colocalizes with N to sites of viral replication and is essential for replication. It plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation. Nsp10 is a critical regulator of coronavirus RNA synthesis and may play an important role in polyprotein processing.
Keywords
SARS-CoV-2 NSP10; SARS-CoV-2
Citations
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