Recombinant Human PIVKA-II (DCP)

Target

PIVKA II

Nature

Recombinant

Tag/Conjugate

Unconjugated

Molecular Weight

70.0 kDa

Alternative Names

PIVKA-II; Prothrombin; DCP

Purity

> 90 % as determined by SDS-PAGE

Format

Liquid

Concentration

Batch dependent - please inquire should you have specific requirements

Buffer

20 mM PB, 150 mM NaCl, pH8.0

Preservative

None

Storage

Store at -20°C

Introduction

Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin's 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin.

Keywords

PIVKA-II; Prothrombin; DCP