Recombinant Human PIVKA-II Protein [His]

Nature

Recombinant

Tag/Conjugate

His

Molecular Weight

72 kDa

Purity

> 95% as determined by SDS-PAGE

Format

Liquid

Buffer

20 mM Tris, 150 mM NaCl, 15% Glycerol, pH 7.0

Preservative

None

Storage

Store at -20°C to -80°C

Introduction

Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin's 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin.

Keywords

PIVKA-II; Prothrombin; DCP