Product Overview
A DNA sequence encoding the human PIVKA-II was expressed with a polyhistidine tag at the C-terminus
Molecular Weight
70.0 kDa
Alternative Names
PIVKA-II; Prothrombin; DCP
Purity
> 95 % as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements
Buffer
10mM PBS, pH7.4, 20% Glycerol
Storage
Store at -20°C to -80°C. Avoid multiple freeze/thaw cycles.
Introduction
Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin's 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin.
Keywords
PIVKA-II; Prothrombin; DCP
Citations
Publication ()
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COA
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