Recombinant HCoV-NL63 S Protein [His] (DAGC133)

Recombinant Human coronavirus NL63 Spike Protein from Insect Cells [His]

Product Overview
A DNA sequence encoding the human coronavirus (HCoV-NL63) spike protein (S1+S2 ECD) (APF29071.1) (Met1-Pro1296) was expressed with a polyhistidine tag at the C-terminus.
Target
HCoV S
Nature
Recombinant
Predicted N terminal
Cys 19
Tag/Conjugate
His
Molecular Weight
142.4 kDa
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
Alternative Names
HCoV NL63; HCoV; NL63; CoV; CoV S Protein
Procedure
None
Purity
> 75 % as determined by SDS-PAGE.
Format
Lyophilized
Size
100 µg
Buffer
Lyophilized from sterile 20 mM PB, 300 mM NaCl, 10 % glycerol, pH 7.6
Preservative
None
Storage
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Introduction
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process.
Keywords
HCoV NL63; HCoV; NL63; CoV; CoV S Protein

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