Recombinant Calprotectin Protein [His]

Nature

Recombinant

Tag/Conjugate

His

Molecular Weight

24 kDa

Alternative Names

Human S100A8 (Myeloid-related protein, MRP 8); S100A9 (MRP14); calgranulin A and B; L1; cystic fibrosis antigen; 27E10 antigen; P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG

Purity

>95%

Format

Liquid

Buffer

Tris Buffer, pH 8.0

Preservative

0.09% Sodium Azide

Storage

2-8°C

Introduction

S100A8/A9, also known as Calprotectin, is a heterodimeric protein that belongs to the family of low molecular weight, calcium binding S100 proteins with two EF-hand calcium binding domains. Calcium and zinc binding influences the S100A8/A9 conformation and oligomerization state, which includes the self-assembly into homo- and heterodimers and larger oligomers. S100A8/A9 is elevated in blood and other body fluids in many pathological conditions including rheumatoid arthritis, inflammatory bowel diseases, viral or microbial infections, and tumors. S100A8/A9 is identified as an endogenous activator of TLR4 and is involved in promoting the inflammatory response in infections. Neutrophil-derived S100A8/A9 inhibits growth of Staphylococcus aureus through the chelation of manganese and zinc. S100A8/A9 is also identified as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread. Injury induced by S100A8/A9 stimulates IP-10 production in monocytes and macrophages. In addition, the S100A8/A9 heterodimer also promotes astrocyte proliferation.

Keywords

Calprotectin; Human S100A8 (Myeloid-related protein; MRP 8); S100A9 (MRP14); calgranulin A and B; L1; cystic fibrosis antigen; 27E10 antigen; P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG