Product Overview
Purified using conventional chromatography procedures. Heterotetramer containing two 8 kDa and two 14 kDa subunits. SDS‐polyacrylamideelectrophoresis of DAG-T1230 Calprotectin antigen showing two subunits of m.wt. 8 and 14 kDa.
Molecular Weight
Calprotectin antigen is seen as a ~48kDa heterotetramer based on the size-exclusion profile observed.
Alternative Names
Protein S100, calgranulin, leucocyte L1 complex, migration inhibitory factor‐related protein, MRP8/14, S100 calcium‐binding protein
Application Notes
Clinical Applications: Faecal calprotectin determination has been shown to be useful in the diagnosis and management of inflammatory bowel disease.
Purity
> 90% by SDS-polyacrylamide electrophoresis.
Concentration
Batch dependent - please inquire should you have specific requirements.
Storage
Store at -80°C. Avoid multiple freeze/thaw cycels
Introduction
Calprotectin is an important calcium signalling protein involved in wound healing. A complex of both MRP14 and MRP8, calprotectin plays a role in vascular inflammation and leukocyte recruitment. Extracellular release of calprotectin during cell damage/stress can be used as a marker for intestinal inflammation. There is growing evidence that faecal calprotectin correlates with mucosal disease activity which can be utilised as a monitoring response to relapse and treatments in inflammatory bowel disease. Measurement of faecal calprotectin is a biochemical test for intestinal inflammation, including inflammatory bowel disease. Under specific clinical scenario, the test may eliminate the need for invasive colonoscopy or radio-labelled white cell scanning.
Keywords
calprotectin antigen, native calprotectin, calprotectin protein
Citations
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