Human Factor H

Name: Human Factor H
SKU: DAG4678
Rating: 5 (1 reviews)

Human Factor H, natural protein

COA

SDS

Datasheet

Summary

Product Overview

Human Factor H

Nature

Native

Tag/Conjugate

Unconjugated

Purity

> 95% by SDS-PAGE

Format

Frozen liquid

Concentration

1.0 mg/ml (see Certificate of Analysis for actual concentration)

Buffer

10 mM sodium phosphate, 145 mM NaCl, pH 7.3

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]

Antigen Description

Complement factor H (fH) is purified from normal human serum. It is an essential regulatory component of the alternative pathway of complement. It is critical for prevention of complement activation on host cells and tissues, especially the kidney. It has

Keywords

CFH; complement factor H; FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; beta-1H; factor H; factor H-like 1; beta-1-H-globulin; H factor 1 (complement); H factor 2 (complement); adrenomedullin binding protein; complement factor H, isoform

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Compliments of Factor H: What's in it for AMD?

IMMUNITY

Authors: Mattapallil, Mary J.; Caspi, Rachel R.

Abstract

Genetic variations in complement factor H (CFH) confer greater risk for age-related macular degeneration (AMD). In this issue of Immunity, Calippe et al. (2017) uncover a non-canonical role for CFH in the inhibition of mononuclear phagocyte elimination from sub-retinal lesions, providing insight into the pathophysiology of AMD associated with CFH variants.

Low levels of serum complement factor H is associated with increasing progression of bronchiectasis

BIOMEDICAL RESEARCH AND THERAPY

Authors: Shettima, Abubakar; Ibrahim, Muhammad M.

Abstract

Introduction: Complement Factor H (CFH) is the major soluble regulatory protein that monitors activation and/or amplification of the complement system. Here, we assess serum levels of complement factor H (CFH) among patients, who were diagnosed with bronchiectasis. Methods: 115 subjects of 80 patients and 35 healthy volunteers were recruited for the study. Blood samples were collected and subjected to centrifugation in order to obtain the serum. The sensitive sandwich ELISA technique, specific for CFH was used for evaluation of CFH in the serum. Results: The age and Body Mass Index (BMI) (expressed as Mean +/- SEM (range)) of the observed bronchiectasis patients and healthy volunteers were 66 +/- 1.13, (30-86) years, 54 +/- 2.37 (27-84) years and 26.14 kg/m(2), 27.4 kg/m(2) respectively. CFH was detected in 27.0% of all subjects examined. It was found to be more common among bronchiectasis patients (18.26%) compared to healthy volunteers (8.70%) (F=0.9362; df=1; p<0.05). Mean CFH concentration was 17.0pg/ml and 9.0pg/ml in bronchiectasis patients and healthy volunteers respectively. FEV1% Pre. FEV1/VC% and CFH levels were found to decrease with increasing severity of bronchiectasis. The association between lung function, CFH levels and severity of disease among bronchiectasis patients was negative, strongly linear (r= -0.9316, r(2) = 0.8678) and statistically significant (p<0.0001). Conclusion: As such, it can be inferred that low level of compliment factor H is related to the progression of bronchiectasis.