Anti-CFH monoclonal antibody, clone PY-35

Water vapor (H2O) is the strongest greenhouse gas in our atmosphere. Hence, accurate measurements and a correct representation in global models of H2O in the upper troposphere/lower stratosphere (UTLS) are important for understanding and projecting climate. Here we compare balloon-borne measurements of UTLS H2O, performed by cryogenic frostpoint hygrometers (CFH) and meteorological radiosondes (Vaisala RS41) during two intensive field campaigns in the Asian summer monsoon anticyclone region, with humidity data from three products of the European Centre for Medium-range Weather Forecasts(ECMWF): operational analysis and forecast (termed OPERA), ERA-Interim reanalysis, and the newly released ERA5 reanalysis. Taking CFH as a reference, we show that OPERA and ERA5 provide a more accurate representation of UTLS H2O than ERA-Interim. In particular, OPERA and ERA5 similarly overestimate H2O mixing ratios by on average 0.7-0.8 ppmv (14-15%) and 0.7-0.9 ppmv (15-17%) at pressures 60-100 hPa, respectively, and both provide a good representation of the observed vertical distribution (including fine structures) and natural variability of UTLS H2O. In contrast, ERA-Interim underestimates UTLS H2O by 0.6-1.7 ppmv (14-30%), and it fails to capture relevant features of the vertical distribution of UTLS H2O. At pressures (p) lower than 60 hPa, all three ECMWF products are in good agreement with CFH. Humidity measurements by RS41 show an average dry bias of 0.1-0.5 ppmv (3-9%) compared to CFH for 60-100 hPa, and a moist bias increasing with altitude for p < 60 hPa, exceeding 100% for p < 40 hPa.

Aneurysmal Fibrous Histiocytoma (AFH) is a distinct and a rare clinicopathological variant of Cutaneous Fibrous Histiocytoma (CFH). It differs from the usual benign fibrous histiocytoma clinically and morphologically with high rate of recurrence. Here, we report a case of AFH with history of recurrence which presented as a polypoid swelling and showed vascular spaces with no endothelial lining which was proved negative by CD34 immunostaining. The spaces were bordered by tumour cells.