Alternative Names
TROVE Domain Family; TROVE3; TROVE domain family
Purity
>90% as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements
Buffer
20mM HEPES, pH 8.0, 150mM NaCl, 1mM DTT, 10% Glycerol
Storage
Store at -20°C. Avoid repeated freeze/thaw cycles
Introduction
Sj gren Syndrome, Subacute Cutaneous LE
The Ro/SS-A antigen is a ribonucleoprotein complex and consists of two major proteins of 52 and 60 kDa, complexed with one specific RNA chain (either hY1, hY2, hY3 or hY5, which all are transcripts of RNA polymerase III); the Ro/SS-A (60 kDa) protein is the RNA-binding protein in the complex. The cellular function of this complex is still unresolved, as is the question whether the antigen is primarily located in the cytoplasm or in the nucleus or even shuttles between the 2 compartments. Ro/SS-A antibodies occur with a prevalence of 60-90% in Sj gren syndrome patients, but also with a prevalence of 25-50% in SLE patients and higher prevalences in subacute cutaneous LE patients. Neonatal lupus syndrome (congenital heart block, photosensitivity, skin lesions) is also associated with the presence of Ro/SS-A autoantibodies in the maternal and neonatal sera, in particular when these autoantibodies are directed to the 52-kDa antigen.
Keywords
TROVE2; Ro60; SSA-60; SS-A 60 kDa antigen; Sjögren's syndrome; Systemic lupus erythematosus; SLE
Citations
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