Anti-ITK monoclonal antibody, clone MAAG4445

Antibody Isotype

IgG

Clone

MAAG4445

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to residues near the C-term of human Emtk/Itk/Tsk was used as immunogen.

Conjugate

Application Notes

WB: 1:1000

Alternative Names

ITK; IL2-inducible T-cell kinase; tyrosine-protein kinase ITK/TSK; EMT; LYK; PSCTK2; kinase EMT; T-cell-specific kinase; tyrosine-protein kinase LYK; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; homolog of mouse T-cell itk/tsk; interleukin-

Entrez Gene ID

UniProt ID

Antigen Description

Emtk/Itk/Tsk is a member of the Tec family of Protein Tyrosine Kinase (PTK) expressed in T, NK, and mast cells. Structurally, Emtk/Itk/Tsk possesses a tyrosine kinase (TK), a pleckstrin homology (PH) and a TEC homology domain. It also contains both SRC homology 2 (SH2) and a SRC homology 3 (SH3) domains. It lacks as well the amino-terminal myristylation signal and the negative autoregulatory phosphorylation site present in all members of the Src family of PTKs. Additionally, the Src tyrosine kinase LCK is required for Emtk/Itk/Tsk activation and recruitment by CD28.

Pathway

Adaptive Immune System, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class I PI3K signaling events, organism-specific biosystem; Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem; Generation of second messenger molecules, organism-specific biosystem;