ITK (NP_005537, 1 a.a. ~ 111 a.a) partial recombinant protein with GST tag. The sequence is MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETR
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
Pathway
Adaptive Immune System; Chemokine signaling pathway; Class I PI3K signaling events; Fc epsilon receptor (FCERI) signaling
Citations
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