Anti-IRS2 monoclonal antibody, clone MAAG566

Antibody Isotype

IgG

Clone

MAAG566

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to residues surrounding Ser1203 of human IRS-2 was used as an immunogen.

Conjugate

Application Notes

WB: 1:5000-20000; IHC: 1:100-250

Alternative Names

IRS2; insulin receptor substrate 2; IRS-2;

Entrez Gene ID

UniProt ID

Q9Y4H2

Antigen Description

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

Pathway

Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem;