Anti-IRS2 monoclonal antibody, clone FQ004Z

Antibody Isotype

IgG

Clone

FQ004Z

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to residues near the N-terminus of human IRS2.

Conjugate

Application Notes

ICC/IF: 1/100 - 1/250; IHC-P: 1/50 - 1/100; IP: 1/50; WB: 1/100,000;

Alternative Names

IRS2; insulin receptor substrate 2; Insulin Receptor Substrate 2; IRS 2; IRS-2; Irs2; IRS2_HUMAN; OTTHUMP00000018696; IRS-2;

Entrez Gene ID

UniProt ID

Antigen Description

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.

Pathway

Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; EPO Receptor Signaling, organism-specific biosystem; EPO signaling pa