Anti-IRS2 monoclonal antibody, clone MAAG3181

Antibody Isotype

IgG

Clone

MAAG3181

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to residues near the N-terminus of human IRS-2 was used as an immunogen.

Conjugate

Application Notes

WB: 1:1000-10000; IHC: 1:50-100

Alternative Names

IRS2; insulin receptor substrate 2; IRS-2;

Entrez Gene ID

UniProt ID

Q9Y4H2

Antigen Description

Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin. After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit. Sequences of IRS-2 and IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain and a phosphotyrosine-binding domain, and a poorly conserved carboxy terminus containing several tyrosine phosphorylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, and may be essential for signaling by several receptor systems such as insulin and cytokine.

Pathway

Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem;