Intended Use
The Monkey anti- Norovirus GI.1 VP1 IgG ELISA Kit is an indirect ELISA suitable for detecting and quantifying IgG antibody activity specific for Norovirus GI.1 VP1 in serum or plasma. Other biological fluids, including tissue culture medium, may be validated for use. The kit is particularly suited to assess the efficacy of various Norovirus vaccines in monkey model. For research use only (RUO).
Storage
The microtiter well plate and all other reagents, if unopened, are stable at 2-8°C until the expiration date printed on the box label. Stabilities of the working solutions are indicated under Reagent Preparation.
General Description
Noroviruses are a genetically diverse group of viruses belonging to the family Caliciviridae. and are the most common cause of gastroenteritis in humans.
Noroviruses can genetically be classified into at least seven different genogroups (GI, GII, GIII, GIV, GV, GVI, and GVII). Genogroups I, II and IV infect humans, genogroup III infects bovine species, and genogroup V has recently been isolated in mice. Most noroviruses that infect humans belong to genogroups GI and GII, with genogroup II, genotype 4 (GII.4) accounting for the majority of adult outbreaks of gastroenteritis. Noroviruses contain a linear, non-segmented, positive-sense RNA genome of approximately 7.5 kilobases encoding a large polyprotein which is cleaved into six smaller non-structural proteins (NS1/2 to NS7) by the viral 3C-like protease (NS6), a major structural protein, VP1, of about 58~60 kDa and a minor capsid protein (VP2).
COA
Publication 
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