Mouse Anti-Human HLA-II monoclonal antibody, clone IVA12

Name: Mouse Anti-Human HLA-II monoclonal antibody, clone IVA12
SKU: DMABC-JX100
Rating: 5 (1 reviews)

Mouse Anti-Human HLA-II monoclonal antibody for FC, IHC, IF, IP, BL

Write a review

COA

SDS

Datasheet

Key features and details

Suitable for FC, IHC, IF, IP, BL
Target: pan-HLA-II. Recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain.
Clonality: Monoclonal
Isotype: Mouse IgG1, κ

Summary

Specifications

Antibody Isotype

IgG1, κ

Clone

IVA12

Species Reactivity

Human

Immunogen

Priess human B cell line

Conjugate

Unconjugated

Applications

Application Notes

FC, IHC, IF, IP, BL
Each laboratory should determine an optimum working titer for use in its particular application.
Other applications have not been tested but use in such assays should not necessarily be excluded.

General Notes

The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.

Target

Alternative Names

MHC class II; MHC II; HLA-II; HLA-DR; HLA-DP; HLA-DQ

Citations